APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis
Identifieur interne : 005124 ( Main/Exploration ); précédent : 005123; suivant : 005125APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis
Auteurs : Sabrina Schilling [France] ; Anita L. Destefano [États-Unis] ; Perminder S. Sachdev [Australie] ; SEUNG HOAN CHOI [États-Unis] ; Karen A. Mather [Australie] ; Charles D. Decarli [États-Unis] ; WEI WEN [Australie] ; Peter H Gh [Danemark] ; Naftali Raz [États-Unis] ; Rhoda Au [États-Unis] ; Alexa Beiser [États-Unis] ; Philip A. Wolf [États-Unis] ; José Rafael Romero [États-Unis] ; Yi-Cheng Zhu [France] ; Kathryn L. Lunetta [États-Unis] ; Lindsay Farrer [États-Unis] ; Carole Dufouil [France] ; Lewis H. Kuller [États-Unis] ; Bernard Mazoyer [France] ; Sudha Seshadri [États-Unis] ; Christophe Tzourio [France] ; Stéphanie Debette [France, États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: We aimed to examine the association of APOE ε genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds. Methods: We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n = 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. When necessary, authors were contacted to provide effect estimates for the meta-analysis. Results: APOE ε4 carrier status and APOE ε44 genotype were associated with increasing white matter hyperintensity burden (sample size-weighted z score meta-analysis [meta]-p = 0.0034 and 0.0030) and presence of cerebral microbleeds (meta odds ratio [OR] = 1.24, 95% confidence interval [CI] [1.07, 1.43], p = 0.004, and 1.87 [1.26, 2.78], p = 0.002), especially lobar. APOE ε2 carrier status was associated with increasing white matter hyperintensity load (z score meta-p = 0.00053) and risk of brain infarct (meta OR = 1.41(1.09, 1.81], p = 0.008). Conclusions: APOE ε4 and APOE ε2 were associated with increasing burden in MRI markers for both hemorrhagic and ischemic CVD. While the association of APOE ε4 with an increased burden of CVD could be partly contributing to the relationship between APOE ε4 and AD, APOE ε2 was associated with MRI markers of CVD in the opposite direction compared to AD.
Affiliations:
- Australie, Danemark, France, États-Unis
- Aquitaine, Massachusetts, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Pennsylvanie, Île-de-France
- Bordeaux, Boston, Paris, Pittsburgh, Sydney, Versailles
- Université de Pittsburgh
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Sachdev</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Neuropsychiatric Institute, Prince of Wales Hospital</s1><s2>Randwick, NSW</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Randwick, NSW</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Centre for Healthy Brain Ageing School of Psychiatry, Faculty of Medicine, University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Seung Hoan Choi" sort="Seung Hoan Choi" uniqKey="Seung Hoan Choi" last="Seung Hoan Choi">SEUNG HOAN CHOI</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Biostatistics, Boston University School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. 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Decarli</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Center for Neuroscience University of California at Davis</s1><s2>Sacramento</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology and Center for Neuroscience University of California at Davis</wicri:noRegion></affiliation></author><author><name sortKey="Wei Wen" sort="Wei Wen" uniqKey="Wei Wen" last="Wei Wen">WEI WEN</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Neuropsychiatric Institute, Prince of Wales Hospital</s1><s2>Randwick, NSW</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Randwick, NSW</wicri:noRegion></affiliation></author><author><name sortKey="H Gh, Peter" sort="H Gh, Peter" uniqKey="H Gh P" first="Peter" last="H Gh">Peter H Gh</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology Copenhagen University Hospital</s1><s2>Roskilde</s2><s3>DNK</s3><sZ>8 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Department of Neurology Copenhagen University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Raz, Naftali" sort="Raz, Naftali" uniqKey="Raz N" first="Naftali" last="Raz">Naftali Raz</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute of Gerontology and Department of Psychology, Wayne State University</s1><s2>Detroit, MI</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Detroit, MI</wicri:noRegion></affiliation></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Biostatistics, Boston University School of Public Health</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Rafael Romero, Jose" sort="Rafael Romero, Jose" uniqKey="Rafael Romero J" first="José" last="Rafael Romero">José Rafael Romero</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Yi Cheng" sort="Zhu, Yi Cheng" uniqKey="Zhu Y" first="Yi-Cheng" last="Zhu">Yi-Cheng Zhu</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Biostatistics Boston University School of Public Health</s1><s2>Boston</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Farrer, Lindsay" sort="Farrer, Lindsay" uniqKey="Farrer L" first="Lindsay" last="Farrer">Lindsay Farrer</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Medicine (Biomedical Genetics), Department of Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Bordeaux Segalen</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Department of Epidemiology GSPH, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Bordeaux Segalen</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen</s1><s3>FRA</s3><sZ>19 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen</wicri:noRegion><wicri:noRegion>CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Bordeaux Segalen</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines</s1><s2>Versailles</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0253699</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0253699 INIST</idno><idno type="RBID">Pascal:13-0253699</idno><idno type="wicri:Area/PascalFrancis/Corpus">000915</idno><idno type="wicri:Area/PascalFrancis/Curation">005570</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B40</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B40</idno><idno type="wicri:doubleKey">0028-3878:2013:Schilling S:apoe:genotype:and</idno><idno type="wicri:Area/Main/Merge">005314</idno><idno 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Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Bordeaux Segalen</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Biostatistics, Boston University School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Neuropsychiatric Institute, Prince of Wales Hospital</s1><s2>Randwick, NSW</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Randwick, NSW</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Centre for Healthy Brain Ageing School of Psychiatry, Faculty of Medicine, University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Seung Hoan Choi" sort="Seung Hoan Choi" uniqKey="Seung Hoan Choi" last="Seung Hoan Choi">SEUNG HOAN CHOI</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Biostatistics, Boston University School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. Mather</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Centre for Healthy Brain Ageing School of Psychiatry, Faculty of Medicine, University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Decarli, Charles D" sort="Decarli, Charles D" uniqKey="Decarli C" first="Charles D." last="Decarli">Charles D. Decarli</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology and Center for Neuroscience University of California at Davis</s1><s2>Sacramento</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology and Center for Neuroscience University of California at Davis</wicri:noRegion></affiliation></author><author><name sortKey="Wei Wen" sort="Wei Wen" uniqKey="Wei Wen" last="Wei Wen">WEI WEN</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Neuropsychiatric Institute, Prince of Wales Hospital</s1><s2>Randwick, NSW</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Randwick, NSW</wicri:noRegion></affiliation></author><author><name sortKey="H Gh, Peter" sort="H Gh, Peter" uniqKey="H Gh P" first="Peter" last="H Gh">Peter H Gh</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology Copenhagen University Hospital</s1><s2>Roskilde</s2><s3>DNK</s3><sZ>8 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Department of Neurology Copenhagen University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Raz, Naftali" sort="Raz, Naftali" uniqKey="Raz N" first="Naftali" last="Raz">Naftali Raz</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute of Gerontology and Department of Psychology, Wayne State University</s1><s2>Detroit, MI</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Detroit, MI</wicri:noRegion></affiliation></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Boston University School of Public Health</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Biostatistics, Boston University School of Public Health</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Rafael Romero, Jose" sort="Rafael Romero, Jose" uniqKey="Rafael Romero J" first="José" last="Rafael Romero">José Rafael Romero</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Yi Cheng" sort="Zhu, Yi Cheng" uniqKey="Zhu Y" first="Yi-Cheng" last="Zhu">Yi-Cheng Zhu</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Biostatistics Boston University School of Public Health</s1><s2>Boston</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Farrer, Lindsay" sort="Farrer, Lindsay" uniqKey="Farrer L" first="Lindsay" last="Farrer">Lindsay Farrer</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Medicine (Biomedical Genetics), Department of Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Bordeaux Segalen</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Department of Epidemiology GSPH, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Bordeaux Segalen</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen</s1><s3>FRA</s3><sZ>19 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen</wicri:noRegion><wicri:noRegion>CNRS-CEA UMR6232 Centre for Imaging-Neuroscience and Application to Pathologies Caen</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Bordeaux Segalen</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>17 aut.</sZ><sZ>19 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology Raymond Poincaré Hospital, University of Versailles St Quentin en Yvelines</s1><s2>Versailles</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Inserm U708 Neuroepidemiology, Salpêtrière Hospital</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology Boston University School of Medicine, Framingham Heart Study</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrovascular disease</term><term>Genotype</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie cérébrovasculaire</term><term>Pathologie du système nerveux</term><term>Génotype</term><term>Imagerie RMN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: We aimed to examine the association of APOE ε genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds. Methods: We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n = 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. When necessary, authors were contacted to provide effect estimates for the meta-analysis. Results: APOE ε4 carrier status and APOE ε44 genotype were associated with increasing white matter hyperintensity burden (sample size-weighted z score meta-analysis [meta]-p = 0.0034 and 0.0030) and presence of cerebral microbleeds (meta odds ratio [OR] = 1.24, 95% confidence interval [CI] [1.07, 1.43], p = 0.004, and 1.87 [1.26, 2.78], p = 0.002), especially lobar. APOE ε2 carrier status was associated with increasing white matter hyperintensity load (z score meta-p = 0.00053) and risk of brain infarct (meta OR = 1.41(1.09, 1.81], p = 0.008). Conclusions: APOE ε4 and APOE ε2 were associated with increasing burden in MRI markers for both hemorrhagic and ischemic CVD. While the association of APOE ε4 with an increased burden of CVD could be partly contributing to the relationship between APOE ε4 and AD, APOE ε2 was associated with MRI markers of CVD in the opposite direction compared to AD.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Danemark</li><li>France</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Pennsylvanie</li><li>Île-de-France</li></region><settlement><li>Bordeaux</li><li>Boston</li><li>Paris</li><li>Pittsburgh</li><li>Sydney</li><li>Versailles</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Schilling, Sabrina" sort="Schilling, Sabrina" uniqKey="Schilling S" first="Sabrina" last="Schilling">Sabrina Schilling</name></region><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><name sortKey="Schilling, Sabrina" sort="Schilling, Sabrina" uniqKey="Schilling S" first="Sabrina" last="Schilling">Sabrina Schilling</name><name sortKey="Schilling, Sabrina" sort="Schilling, Sabrina" uniqKey="Schilling S" first="Sabrina" last="Schilling">Sabrina Schilling</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Zhu, Yi Cheng" sort="Zhu, Yi Cheng" uniqKey="Zhu Y" first="Yi-Cheng" last="Zhu">Yi-Cheng Zhu</name></country><country name="États-Unis"><noRegion><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name></noRegion><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stéphanie" last="Debette">Stéphanie Debette</name><name sortKey="Decarli, Charles D" sort="Decarli, Charles D" uniqKey="Decarli C" first="Charles D." last="Decarli">Charles D. Decarli</name><name sortKey="Farrer, Lindsay" sort="Farrer, Lindsay" uniqKey="Farrer L" first="Lindsay" last="Farrer">Lindsay Farrer</name><name sortKey="Farrer, Lindsay" sort="Farrer, Lindsay" uniqKey="Farrer L" first="Lindsay" last="Farrer">Lindsay Farrer</name><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name><name sortKey="Rafael Romero, Jose" sort="Rafael Romero, Jose" uniqKey="Rafael Romero J" first="José" last="Rafael Romero">José Rafael Romero</name><name sortKey="Raz, Naftali" sort="Raz, Naftali" uniqKey="Raz N" first="Naftali" last="Raz">Naftali Raz</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Seung Hoan Choi" sort="Seung Hoan Choi" uniqKey="Seung Hoan Choi" last="Seung Hoan Choi">SEUNG HOAN CHOI</name><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name></country><country name="Australie"><noRegion><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name></noRegion><name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. Mather</name><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name><name sortKey="Wei Wen" sort="Wei Wen" uniqKey="Wei Wen" last="Wei Wen">WEI WEN</name></country><country name="Danemark"><noRegion><name sortKey="H Gh, Peter" sort="H Gh, Peter" uniqKey="H Gh P" first="Peter" last="H Gh">Peter H Gh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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